Summoners!
Here’s my guide for Act 4.2.2 “The Guillotine Drops” in Marvel Contest of Champions.

General Thoughts:
When you get into Act 4.2.2 you’re going to see more of the purple Link Nodes. Most of the links are simple Attack, Health, or Armor boosts so they shouldn’t roadblock you. The one fight to really be aware of is the Debuff-Immune Ronan on the left side of the map. None of your Damage-Over-Time debuffs will work in this fight, and you won’t be able to Stun him unless the champion you bring has access to a Passive Stun effect. Be prepared to bait Ronan’s Heavy Attack and SP1 to get openings.
During my run through Act 4.2.2 I reached Level 43, and added a second point to Mystic Dispersion and unlocked the Pierce Mastery. My 5-Star Captain America Infinity War reached 4/55, and 4-Star Aarkus reached 5/50. I also brought 4-Star Yondu to Rank 5 and Dragon Man to Rank 4.
If you have questions about the basic attack moves and combos in Marvel Contest of Champions, please check out my MCOC 101: Combos guide.
Best Champs: Any
Restrictions: None
Global Node: None
Boss: Cyclops New Xavier School
Boss Notes:
Local Nodes:
Checkmate
Combo Shield
+100% Health
Parry
Link Nodes
+25% Attack & Health (3)
Even with the boosts this is still a standard Cyclops. Just bait his SP1 and you’ll be fine.
Lane 1 – Far Left
Gate: None
Defenders: Gamora, Iron Man, Ronan, Abomination, Rhino, Ronan, Hawkeye, Hawkeye, Yellowjacket, Daredevil, Juggernaut, Storm, Captain Marvel Classic
Nodes: +25% Attack & Health, Debuff Immune, Special Lock 2 (Ronan), 2x +25% Attack & Health (Juggernaut, Storm), 3x +25% Attack & Health, +100% Attack, +100% Critical Damage (Captain Marvel Classic)
Team: 6-Star Red Skull, 5-Star Captain America Infinity War, 4-Star Black Widow Deadly Origin, 4-Star Emma Frost, 4-Star Man-Thing
Tips: Remember that by virtue of being Debuff Immune, you can’t Parry-Stun Ronan. Captain Marvel Classic hits pretty hard so be careful there.
Lane 2 – Left to Ronan & Up
Gate: None
Defenders: Gamora, Iron Man, Ronan, OG Vision, Hulk, Electra, Iron Man, Hawkeye, Yellowjacket, Daredevil, Juggernaut, Storm, Drax
Nodes: +25% Attack & Health, Debuff Immune, Special Lock 2 (Ronan), 3x +25% Attack & Health, +100% Attack, +100% Critical Damage (Captain Marvel Classic)
Team: 6-Star Red Skull, 5-Star Captain America Infinity War, 4-Star Black Widow Deadly Origin, 4-Star Aarkus, 4-Star Man-Thing
Tips: Other than Debuff-Immune Ronan these are very easy fights.
Lane 3 – Left Center
Gate: None
Defenders: Gamora, Iron Man, Daredevil, Captain America, Star-Lord, Storm, Thor, Magik, Captain Marvel Classic
Nodes: +25% Attack & Health (Star-Lord, Storm, Thor, Magik), +90% Armor, Energize 1, +100% Attack, +100% Critical Damage, +25% Attack & Health (Captain Marvel Classic)
Team: 6-Star Red Skull, 5-Star Captain America Infinity War, 4-Star Black Widow Deadly Origin, 4-Star Emma Frost, 4-Star Man-Thing
Tips: There isn’t much to worry about here. Bring a True Strike or Damage-over-Time champion to get around the Armor Node on the mini-boss.
Lane 4 – Center Right – Easy Path
Gate: None
Defenders: Gamora, Magneto, Star-Lord, Wolverine, Star-Lord, Black Panther, War Machine, Magik, Drax
Nodes: +90% Armor, Energize 1, +100% Attack, +100% Critical Damage (Captain Marvel Classic)
Team: 5-Star Captain America Infinity War, 4-Star Red Guardian, 4-Star Sorcerer Supreme, 4-Star Sabretooth, 4-Star Man-Thing
Tips: This is the easiest path to the boss as it clears up most of the Link Nodes. There isn’t anything tricky to worry about here.
Lane 5 – Right & Up to Ronan
Gate: None
Defenders: Gamora, Magneto, Hawkeye, Ronan, Electra, Hulk, Iron Man, Ronan, Hulk, War Machine, OG Vision, Unstoppable Colossus, Magneto, Drax
Nodes: +80% Physical Resistance, +80% Energy Resistance, Special Lock 2 (Hawkeye), 2x +25% Attack & Health (Unstoppable Colossus, Magneto), +90 % Armor, Energize 1, 2x +25% Attack & Health (Drax)
Team: 6-Star Red Skull, 5-Star Captain America Infinity War, 4-Star Black Widow Deadly Origin, 4-Star Aarkus, 4-Star Man-Thing
Tips: Bring a champion that does Bleed or Poison damage for Hawkeye to circumvent his damage resistances.
Lane 6 – Far Right
Gate: None
Defenders: Gamora, Magneto, Hawkeye, Spider-Man, Yellowjacket, Hulk, Abomination, Rhino, Hulk, War Machine, OG Vision, Unstoppable Colossus, Magneto, Drax
Nodes: +80% Physical Resistance, +80% Energy Resistance, Special Lock 2 (Hawkeye), 2x +25% Attack & Health (Unstoppable Colossus, Magneto), +90 % Armor, Energize 1, 2x +25% Attack & Health (Drax)
Team: 6-Star Red Skull, 5-Star Captain America Infinity War, 4-Star Black Widow Deadly Origin, 4-Star Aarkus, 4-Star Man-Thing
Tips: Bring an evade counter for the duped Spider-Man and a Poison-Immune champion for the hidden Abomination. Skill champions are good for this lane because there are so many Science defenders.
My Roster:

Jump To:
Act 4.1.6 – “Trust” – Level 41
Act 4.2.1 – “Linked Might” – Level 42
Act 4.2.2 – “The Guillotine Drops” – Level 43
Act 4.2.3 – “Straight Outta Queens” – Global Nodes
Act 4.2.4 – “Asgard’s Champion” – Level 44
Act 4.2.5 – “Dark Presence” – Level 45
Act 4.2.6 – “Defiance” – Hidden Roadblock
Act 4.3.1 – “Triumphant Return” – Level 46
-Dano357
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